• Wortmannin The imbalance that renders greater

  2020-08-10

  

  The imbalance that renders greater lipid uptake toxic is unclear, but the comparison of our in vitro studies with those in mice illustrates the importance of TAG storage versus accumulation of less non-polar molecules. Protective effects of ACSL1 and PPARγ have been reported in other cell types. Par

• Twin studies have shown that P

  2020-08-09

  

  Twin studies have shown that P has moderate heritability. Zuckerman (1989) reviewed the earlier studies of P or related traits and found a median heritability of 0.51. However, twin studies using an Eysenckian P scale have tended to estimate somewhat lower heritabilities than this, in the range 0.36

• The crystal structure of full length CHK is still

  2020-08-08

  

  The crystal structure of full-length CHK is still unsolved. However, the close homology between CHK and Csk suggests that these kinases share a similar structure. Therefore, the engagement of the CHK SH2–kinase linker with the αC-helix could control the activity of the CHK kinase domain. Sequence al

• Metakaolin is the product of

  2020-08-08

  

  Metakaolin is the product of calcination of kaolinite rich clay at temperatures between 600 and 850 °C [11], [12] depending on the purity and the crystallinity of the initial clay. The geopolymers from metakaolin as aluminosilicate source have shown promising results in previous works [13], [14], [1

• Recent studies reported on the dependency of tumors

  2020-08-08

  

  Recent studies reported on the dependency of tumors with mutant RAS on SHP2 (Fedele et al., 2018, Mainardi et al., 2018, Nichols et al., 2018, Ruess et al., 2018). Consistent with those studies, we found RAS(G12X) mutants, but not RAS(Q61X), to be dependent on SHP2. However, although Mainardi et al.

• br Expression data suggest involvement of additional TRIMs

  2020-08-08

  

  Expression data suggest involvement of additional TRIMs in heart function Given the complexity of the cardiac function, involved molecular pathways and processes, and the fact that only a few of the TRIMs have thus far been shown to have a cardiac role, we hypothesized that there would be more TR

• In addition to its pro inflammatory action DDR controls

  2020-08-07

  

  In addition to its pro-inflammatory action, DDR1 controls collagen synthesis. Mice lacking DDR1 show increased fibrillar collagen deposition in the mammary gland [20] and DDR1-null smooth muscle show increased mRNA levels of fibrillar collagens I and III [21], suggesting that DDR1 is a negative regu

• For plasma cell differentiation BCRs in post GC plasma cells

  2020-08-06

  

  For plasma cell differentiation, BCRs in post-GC plasma cells are heavily dominated with a high-affinity mutation, even at a time point when this mutation is present in only a small fraction of GC cells (Phan et al., 2006). Hence, higher-affinity cells are directed to the plasma cell fate, whereas l

• Collagen II is the major collagen

  2020-08-06

  

  Collagen II is the major collagen found in cartilage. The collagen II triple helix is a homotrimer of three α1 chains. We have been interested in mapping the functional domains of the collagen II triple helix and developed a cDNA cassette system for recombinant production of collagen II variants. Us

• Several known selective CSF R inhibitors bind the enzyme in

  2020-08-06

  

  Several known selective CSF-1R inhibitors bind the enzyme in a DFG-out mode. For example, is exquisitely selective for CSF-1R (b)., , An important feature of this co-crystal structure is the bidentate hydrogen bonding network made by the oxygen atoms of the methoxy and benzyloxy groups of the ‘DFG

• Most recently it has been described

  2020-08-06

  

  Most recently, it has been described that cPLA2α activity contributes to the phagosomal escape of Mycobacterium tuberculosis [73,74]. The enzyme appears to facilitate translocation of the microbe from the endosomal to the cytosolic compartment of human THP-1 macrophage-like cells, allowing survival

• While desolvation appears to play a

  2020-08-05

  

  While desolvation appears to play a universal role in the binding of the nucleotide substrate during TLS, the molecular forces regulating the polymerization step are more divergent as they depend upon the physical nature of the DNA lesion. For instance, π-stacking interactions play a large role in f

• Typical examples of CO utilization and

  2020-08-05

  

  Typical examples of CO2 utilization and reduction technologies are catalytic reduction of CO2 to C1 compounds such as CO, formic acid, methanol and so on [[3], [4], [5], [6], [7], [8], [9], [10]], and catalytic organic synthesis using CO2 as a feedstock [[11], [12], [13], [14], [15], [16], [17], [18

• There is increasing evidence implicating NFY as a key player

  2020-08-05

  

  There is increasing evidence implicating NFY as a key player in cancer development. NFY binds the CCAAT box which is present in about 30% of eukaryotic promoters [23]. It is reported that promoters that lack a TATA box rely greatly on the CCAAT box for transcriptional activation [18], and we show th

• br IGF signaling pathway inhibitors The importance of the

  2020-08-05

  

  IGF signaling pathway inhibitors The importance of the IGF pathway to sarcoma biology including Ewing sarcoma has been the subject of decades of investigation. A number of important studies have established the importance of this pathway to the biology of Ewing sarcoma. In particular, IGF has bee

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